Tag archives: difficulty walking

The adorable Yorkshire terrier has become an important fixture in American households since its introduction to the United States in the late 19^th century. Originally bred in Scotland and going by the name “Scotch terrier”, the Yorkshire terrier was given its modern name after great improvements in the breed were made in the county of Yorkshire in northern England.

Like most dog breeds, the Yorkie has developed some inherited diseases on its path to the modern breed. The genetic mutations responsible for some better known, inherited diseases of Yorkies such as primary lens luxation (PLL) and a form of progressive retinal atrophy known as progressive rod-cone degeneration (PRA-prcd) have been identified. The identification of these mutations has made it possible for Yorkie breeders to test their dams and sires prior to breeding and to use informed selective breeding practices to prevent the birth of puppies with these conditions. While most Yorkie breeders are familiar with PLL and PRA-prcd in the breed, another inherited condition known as degenerative myelopathy (DM) is less well known by Yorkie breeders. However, DM may be a concern worth investigating further in the Yorkie as the associated mutation has been identified in the breed.

What ...

Neuronal Ceroid Lipofuscinosis (NCL) is a group of inherited mammalian diseases characterized by abnormal accumulations of a metabolic byproduct known as lipofuscin in nerve cells and various organs of the body.  The accumulation of lipofuscin eventually leads to progressive nerve cell dysfunction and severe neurological symptoms including behavioral changes, balance issues, muscle atrophy, uncoordinated movement, blindness, head tremors and seizures.  Other organ systems can also be affected to various degrees depending on the severity of lipofuscin build up.  Most dogs will die due the disease or are euthanized when neurologic problems progress to the point of preventing normal daily activities.  While most types of NCL begin to cause clinical signs around 1 to 2 years of age in dogs, the age of onset and speed of progression vary significantly upon the type of NCL.  Variable presentation and progression among NCL types is expected given that multiple genes can cause this clinical condition.

Unfortunately, details about disease incidence and prevalence within a breed are often difficult to obtain including NCL.  Without going into an in-depth discussion about statistics, among other conditions, in order to estimate incidence and prevalence of disease for an entire population, individuals ...